Yankees Opening Day 2025 Time Team. Mlb opening day will take place on thursday, march 28. The new york yankees will open the home portion of their 2025 regular season schedule on friday, april 5, at 1:05 p.m.

Time to project the starting lineup. The yankees will open up their season against the houston astros, and the game will take place at 4:10 pm edt on match 28.